The Pan American Health Organization (PAHO) issued an epidemiological alert, calling on nations in the Americas region to strengthen vaccination, surveillance, and response amid a rising number of measles cases.
Objectively measured physical fitness was associated with lower all-cause mortality in older adults in a recent study. The findings, published in JAMA Network Open, could have implications for clinical care, the authors said.
This Medical News article discusses the estimated population-level effects of the 2025 blood pressure guideline, which expanded antihypertensive treatment eligibility.
This Medical News article discusses a new scientific statement from the American College of Cardiology about caring for older adults with cardiovascular disease.
The ADVOCATE initiative and how autonomous AI agents could help patients with heart failure are discussed by JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, and Haider Warraich, MD, a cardiologist and the program manager at ARPA-H, for the JAMA+ AI Conversations podcast.
In this narrative medicine essay, a maternal-fetal medicine physician trained to use clinical terms for developmental stages of pregnancy as an emotional stay against an uncertain outcome experiences tension between clinical and lived language during his wife’s miscarriage.
The Original Investigation titled “Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis,” published on October 3, 2023, was corrected to update Supplement 2. In the original supplement, eTable 21 and eTable 22 were identical and did not have the correct information…
Medicine trains clinicians in a particular silence. Through diagnosis, we medicalize the causes of suffering—contusion, laceration, hemorrhage—as though renaming anguish might contain it, keeping it from spilling out of charts and into our own lives. Operating room and ward become, ironically, fluent in the language…
The Original Investigation titled “Global Burden of Elevated LDL-C: Findings From the Global Burden of Disease Study 2023,” published July 29, 2026, was corrected to update the author affiliations list. This article was corrected online.
This Viewpoint discusses how consolidation in frontline care delivery has shaped health care markets across the US and how changes in ownership of hospitals and practices affect clinicians and patient outcomes.
In the JAMA Clinical Guidelines Synopsis titled “Antiviral Therapies for Adults With Mild to Moderate COVID-19 Infection,” published online June 30, 2026, several points were rewritten for clarification. In the third paragraph of the Evidence Base section, the second sentence was revised to “Coadministration of…
To the Editor Dr Renú and colleagues reported that adjunctive intra-arterial alteplase after successful thrombectomy “may improve functional recovery” in large vessel occlusion stroke. The randomized clinical trial provides an important test of a plausible reperfusion strategy, but the report leaves a key issue unresolved—the…
In Reply As described in the original report, the primary outcome was amended at month 12 to improve clinical relevance and interpretability, considering emerging randomized evidence and the established use of the blinded mRS score assessment. The amendment was implemented on February 10, 2025, after…
To the Editor I appreciate the expanded women’s health learning opportunities provided by the JAMA Network journals under the editorial leadership of Linda Brubaker, MD, MS. The comprehensive Review of prepregnancy care and counseling by Dr Cooper and colleagues will be a valuable resource for…
To the Editor In reading the otherwise comprehensive article by Dr Cooper and colleagues on prepregnancy care and counseling, we were surprised by the lack of discussion about testing for iron deficiency. Iron deficiency, the world’s most common micronutrient deficiency, is epidemic in young women…
In Reply We thank Dr Barbieri and Drs Auerbach and DeLoughery for their comments. With regard to Barbieri’s Letter on HCV screening, the US Preventive Services Task Force recommendation is for adults aged 18 to 79 years. We agree with screening reproductive-aged female patients for…
This Perspective discusses the ethical, scientific, clinical, and manufacturing implications of excluding patients living with HIV from gene therapies for sickle cell disease.
To the Editor Dr Patel and colleagues reported that the national launch of the 988 Suicide and Crisis Lifeline was associated with an 11% reduction in adolescent and young adult suicide deaths (4372 fewer than expected). These findings suggest that a phone-based open-access crisis service…
To the Editor Dr Patel and colleagues’ recent article provided promising evidence that the 988 Suicide and Crisis Lifeline has been successful at preventing suicide death. Indeed, their results comparing “high-uptake” and “low-uptake” states are consistent with a time-series analysis of pre–988 Lifeline data that…
In Reply We thank Dr Herring and Dr Purtle for their thoughtful comments. Our study found that suicide mortality among adolescents and young adults decreased after the national launch of the 988 Lifeline, that declines were largest in states where the 988 Lifeline uptake increased…
Prostate cancer has long served as a fertile ground for innovation in cancer therapy. Compared with many other malignancies, localized prostate cancer occupies a unique clinical space. Although the incidence of new diagnoses is high, prostate cancer often follows an indolent natural history, resulting in…
This randomized clinical trial assesses whether stereotactic body radiotherapy is superior to moderately hypofractionated intensity-modulated radiation therapy in terms of patient-reported urinary irritative/obstructive and bowel quality of life and disease-free survival in patients with localized intermediate-risk prostate cancer.
The objective of this study was to assess whether stereotactic body radiotherapy (SBRT) was superior to moderately hypofractionated intensity-modulated radiation therapy (MH-IMRT) for urinary and bowel quality of life and disease-free survival in patients with localized intermediate-risk prostate cancer.
This randomized trial assesses the effect of use of total intravenous anesthesia on days alive and at home 30 days after surgery among older adults undergoing major noncardiac surgery.
This trial examined whether general anesthesia maintenance with total intravenous anesthesia (TIVA) improves patient outcomes compared with volatile-based inhalational anesthesia among adults aged ≥50 years undergoing major elective noncardiac surgery.
This JAMA Insights examines the use of nicotine pouches in the US, including adverse effects, comparisons with cigarette and e-cigarette use, and concerns regarding increased use among adolescents and young adults.
An estimated 250 million children in low- and middle-income countries are unable to meet key developmental milestones due to biological, psychological, and social risk factors, including maternal and child malnutrition, maternal depression, and inadequate early stimulation opportunities. Without early intervention, these adversities pose threats to…
This randomized trial assesses the effect of an integrated intervention package including health, nutrition, early child stimulation, and maternal psychosocial support on weight and weight-for-age z scores among term small-for-gestational-age (SGA) infants in a low-resource setting.
This clinical trial investigated whether an integrated health, nutrition, and early stimulation intervention during infancy improves growth in term small-for-gestational-age (SGA) infants.
This JAMA Clinical Guidelines Synopsis summarizes the American College of Gastroenterology’s (ACG) 2025 clinical guideline update on management of ulcerative colitis in adults.
Alzheimer disease is defined by the accumulation of extracellular amyloid-β plaques and intraneuronal neurofibrillary tangles composed of hyperphosphorylated tau. For many years, drug development efforts have focused on amyloid-β plaques, culminating in the recent approval of the amyloid-targeting monoclonal antibodies lecanemab and donanemab for the…
This randomized clinical trial examines the efficacy and safety of the potent oral O-linked N-acetylglucosaminidase inhibitor ceperognastat in early symptomatic Alzheimer disease.
This study evaluated whether the oral O-linked N-acetylglucosaminidase inhibitor ceperognastat, at doses of 0.75 and 3 mg, compared with placebo, slows clinical progression in patients with early symptomatic Alzheimer disease with low to medium tau levels.
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