Martes 29 de septiembre de 2026 · 152 publicaciones en las últimas 24 h · 29 fuentes · actualizado hace 22 min
Artículos recién publicados en revistas médicas con revisión por pares, de Estados Unidos, Europa y América Latina. Los preprints de medRxiv se marcan aparte: son resultados preliminares que todavía no pasan revisión por pares.
139 notas · Solo en español
The UK prime minister has set out details of his radical plan to create a national care service in England, saying it would be as significant as the creation of the NHS.In a speech at the Labour party’s annual conference in Liverpool, Andy Burnham said…
As technology companies and governments race to advance artificial intelligence (AI), there has been a proliferation of large, energy intensive data centres. Alongside data centres’ potential to increase people’s energy costs, the facilities have also subjected a growing number of communities to a surge in…
by Po-Huang Chen, Ming-Shen Dai, Mao-Hsuan Huang, Hsin-Yu Chen, Li-Ting Kao, Tina Yi-Jin Hsieh, Hong-Jie Jhou, Cho-Hao Lee Background Preclinical evidence identifies the serotonin transporter (SERT, encoded by SLC6A4) as an immune checkpoint on CD8+ T cells, with selective serotonin reuptake inhibitors (SSRIs) enhancing antitumor…
by Kavita Singh, Ambuj Roy, Dimple Kondal, Kalyani Nikhare, Mareesha Gandral, Satish G. Patil, Kiran Aithal, M. P. Girish, Mohit Gupta, Kushal Madan, J. P. S. Sawhney, Kamar Ali, Meetushi Jain, Savitesh Kushwaha, Devraj Jindal, Emily Mendenhall, Shivani A. Patel, K. M. Venkat Narayan, Nikhil…
by Saraid McIlvride, Neha Rao, Sarjit Singh, Scott M. Nelson, Jill P. Pell, Michael Fleming Background The long-term effects of antidepressant use in pregnancy on child neurodevelopment are unclear; meanwhile antidepressant use in pregnancy is increasing. We aimed to clarify associations between prenatal maternal depression…
Several of the largest news organisations in the Netherlands have been fined thousands of euros for what regulators said was the unlawful promotion of GLP-1 medications.Dutch healthcare regulator the Health and Youth Care Inspectorate (IGJ) issued fines to a range of newspapers, magazines, and television…
Blood tests have found high concentrations of the carcinogen perfluorooctanoic acid (PFOA) in residents in Thornton-Cleveleys, Lancashire, who live near a chemical factory.Who ordered the blood tests for PFOA, and why?The blood tests were commissioned by the law firm Leigh Day, working with Manchester Metropolitan…
Heidi Overton, Donald Trump’s nominee to head the US Food and Drug Administration (FDA), has refused to diverge from the president on controversial health policies, including his plan to split the MMR vaccine into separate injections.In a senate hearing on 24 September, the first major…
Livingston discusses research on the early effects of Australia’s social media ban for children under 16.1 We agree with the importance of taking precautions, but think that, instead of focusing primarily on restricting adolescents’ access to social media, greater emphasis should be on teaching them…
Nature Medicine, Published online: 29 September 2026; doi:10.1038/s41591-026-04693-z In a phase 1 trial, inhibition of the Werner syndrome helicase (WRN) enzyme exploits a new synthetic lethal vulnerability in cancers with microsatellite instability, offering a new way to target these tumors beyond immune checkpoint inhibition.
Nature Medicine, Published online: 29 September 2026; doi:10.1038/s41591-026-04651-9 The OUTSTAND-1 trial showed that once-daily oral small-molecule GLP-1 receptor agonist safiglipron reduced HbA1c by up to 1.45% versus placebo over 32 weeks in people with type 2 diabetes without glucose-lowering medication while body weight effects were…
Nature Medicine, Published online: 29 September 2026; doi:10.1038/s41591-026-04657-3 In the dose-escalation stage of a phase 1 trial evaluating RO7589831, a first-in-class inhibitor of the synthetic lethal target Werner syndrome helicase, in patients with microsatellite instability and/or DNA mismatch repair-deficient solid tumors, the maximum tolerated dose…
Nature Medicine, Published online: 29 September 2026; doi:10.1038/s41591-026-04667-1 Reproducibility is a foundational principle of trustworthy science, but reproducible research practices are not consistently implemented. This Review summarizes the current landscape including efforts to harmonize terminology and implementation, persistent barriers and ecosystem responses.
Los estilos de vida no saludables están vinculados a un mayor riesgo de mortalidad; sin embargo, esta relación podría ser más pronunciada en personas con bajo nivel educacional. Objetivo: Analizar la asociación entre estilos de vida no saludables y la mortalidad en una cohorte…
La esclerosis múltiple (EM) es una enfermedad crónica del sistema nervioso central que afecta principalmente a adultos jóvenes. Además de síntomas físicos, la EM impacta de forma significativa en la salud mental y la calidad de vida. En Chile existe escasa información sobre estos…
Con el envejecimiento poblacional, la fragilidad física se ha convertido en tema de interés en salud pública. En Chile existen escasos estudios longitudinales que identifiquen predictores desde un enfoque integral. Objetivo: Identificar variables sociodemográficas, de salud mental, soledad y clínicas predictoras de fragilidad física…
La neumonía asociada al ventilador (NAV) es una de las enfermedades infecciosas con mayor mortalidad debido al aumento de la resistencia bacteriana a los antibióticos. Por ello, un diagnóstico temprano y tratamiento dirigido contra el agente etiológico es fundamental. El uso del panel para…
Las personas trans en terapia hormonal de afirmación de género (THAG) presentan vulnerabilidades nutricionales, cardiometabólicas y psicosociales poco descritas en Chile. Objetivo: Caracterizar dichos perfiles en personas atendidas en el policlínico de género adulto del Hospital Dr. Hernán Henríquez Aravena de Temuco. Métodos: Se…
CardiologíaDiabetes, obesidad y metabolismoNutrición y hábitos
La diabetes mellitus tipo 2 (DM2), la obesidad, la enfermedad renal crónica (ERC) y la insuficiencia cardíaca (IC) representan un problema de salud pública en Chile y América Latina. Los agonistas del receptor de GLP-1 (AR-GLP-1), además de su efecto hipoglicemiante, han demostrado beneficios…
El desarrollo de tecnologías de Inteligencia Artificial (IA) ha generado un impacto notable en las metodologías educativas, especialmente en la educación superior (ES). Por esto, se realiza una revisión narrativa de la literatura disponible. Su influencia se refleja en la docencia, la investigación, la…
La enfermedad de Cushing (EC) es una enfermedad endocrinológica caracterizada por un exceso en la producción de hormona adrenocorticotropa (ACTH) por la adenohipófisis, lo que determina un aumento en la producción de cortisol en las glándulas suprarrenales y manifestaciones clínicas secundarias. El diagnóstico diferencial…
La enfermedad de Cushing (EC) es una enfermedad endocrinológica caracterizada por un exceso en la producción de hormona adrenocorticotropa (ACTH) por la adenohipófisis, lo que determina un aumento en la producción de cortisol en las glándulas suprarrenales y manifestaciones clínicas secundarias. El diagnóstico diferencial…
Infectología y vacunasDiabetes, obesidad y metabolismoNutrición y hábitos
La enfermedad de Cushing (EC) es una enfermedad endocrinológica caracterizada por un exceso en la producción de hormona adrenocorticotropa (ACTH) por la adenohipófisis, lo que determina un aumento en la producción de cortisol en las glándulas suprarrenales y manifestaciones clínicas secundarias. El diagnóstico diferencial…
by Manpreet Kaur, on behalf of the PLOS Medicine Staff Editors Cardiovascular disease is a leading cause of death, and progress in reducing mortality has stalled, calling for more research. An opportunity lies in harnessing cardiovascular data from smartwatches. However, ethical and logistical barriers need…
by Laura A. Magee, Peter von Dadelszen, Kypros H. Nicolaides Summary points Traditional antenatal care consists of an accelerating frequency of visits with advancing gestational age, as the bulk of pregnancy complications occur in late pregnancy. The ‘inverted pyramid of care’ concept describes a focus…
Nature Medicine, Published online: 28 September 2026; doi:10.1038/s41591-026-04698-8 When detecting Ebola is not enough: closing the response interval in DRC
Nature Medicine, Published online: 28 September 2026; doi:10.1038/d41591-026-00049-9 A technique known as prime assembly expands the capabilities of prime editing, allowing larger genome rearrangements and potentially wider clinical applications.
Nature Medicine, Published online: 28 September 2026; doi:10.1038/d41591-026-00048-w Using data from over 3 million people, researchers trace the ancestral history of the EGFR T790M germline mutation and its present contribution to lung cancer risk in those who never smoked.
Nature Medicine, Published online: 25 September 2026; doi:10.1038/s41591-026-04684-0 Polygenic scores in the NHS: the debate is not primarily about the evidence
by Kanna Hayashi, Eric C. Sayre, Jennifer McDermid, Samona Marsh, Caitlin Shane, Michael-John Sheridan Milloy, P.O.W.E.R. , Thomas Kerr Background Housing is a key determinant of health. In response to increasingly visible homelessness amid a growing housing crisis, many jurisdictions in North America forcibly displace…
by Luan Nguyen Quang Vo, Thuy Thi Thu Dong, Huy Ba Huynh, Binh Anh Luong, Huong Thi Lan Mo, Andrew James Codlin, Rachel Forse, Thuy Doan To Mai, Lan Phuong Nguyen, Jacob Creswell, Luong Van Dinh, Hoa Binh Nguyen, Phu Xuan Vu, Tuan Dinh Nguyen…
by Oladipupo Olalere, Min-Dee Koh, Katie Crabb, Olanike Ajijola, Saba Tariq, Chau Thien Tay, Aya Mousa, Soha Sobhy, Lynne Robinson, Rima Dhillon-Smith, Kathy Hoeger, Lisa Moran, Helena Teede, Shakila Thangaratinam Background Lifestyle interventions are recommended as first-line treatment in polyendocrine metabolic ovarian syndrome (PMOS), but…
BackgroundPost-acute COVID-19 syndrome (PACS) can cause persistent disability involving fatigue, post-exertional malaise, neurocognitive symptoms, and autonomic manifestations. A clinically overlapping condition has been reported following COVID-19 vaccination and termed post-acute COVID-19 vaccination syndrome (PACVS), but its underlying mechanisms remain poorly understood. We investigated whether immune…
BackgroundCancer-associated fibroblasts (CAF) are major regulators of the tumor microenvironment (TME), yet the pathways governing CAF function remain incompletely understood. Type 2 deiodinase (DIO2, D2), which converts thyroxine (T4) to the active thyroid hormone triiodothyronine (T3), has not been systematically investigated in CAF across different…
Disorders of consciousness (DoC) are characterised by marked reductions in cerebral glucose metabolism, but the specific cellular and neurochemical processes driving this impairment remain unclear. To elucidate these mechanisms, a multimodal imaging approach combining [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance spectroscopy (MRS) was…
Depression is one of the most prevalent mental health disorders globally. Social media content can reflect emotional states, offering real-time signals of depressive symptoms. This study aimed to develop a deep learning model to predict depression using Twitter/X data, and to characterize potential causes of…
ObjectivesTo estimate the prevalence of objective peripheral neuropathy, and to test whether self-reported use of personal protective equipment (PPE) is associated with lower neuropathy risk, among adults attending a community hospital in a Nigerian population exposed to both agrochemicals and mining. DesignClinic-based cross-sectional study (June-November…
ObjectiveThe Concise Health Risk Tracking (CHRT) assessment has utility in suicide risk prediction in adults and adolescents. Because multi-informant assessment is the gold standard in pediatric populations, a parent report version of the CHRT may enhance evaluation of youth suicide risk. We adapted the self-report…
Individuals with Down syndrome (DS) exhibit accelerated biological aging and unique patterns in disease prevalence. However, empirical characterizations of relative risk and age at onset of disease in this population are not common. Here we aimed to quantify the difference in risk and timing of…
Background and aimsCrohns disease (CD) is a highly heterogeneous disease. Patients with similar characteristics at baseline may end up on very different therapeutic and surgical paths. We aimed to identify disease-course trajectory phenotypes from a mix of clinical, treatment, surgical and comorbidity variables, and evaluate…
Mostramos el titular, un extracto breve y el enlace a cada nota; el contenido completo y sus derechos son de cada medio. Las notas se recogen automáticamente de los canales RSS públicos de las fuentes cada 30 minutos y se clasifican por especialidad con palabras clave, así que alguna puede quedar en una sección que no le corresponde. Una noticia no es una recomendación clínica: antes de cambiar una conducta, revisa el artículo original y las guías vigentes. ¿Eres editor de un medio y prefieres no aparecer? Escríbenos. Suscríbete por RSS.