Martes 29 de septiembre de 2026 · 152 publicaciones en las últimas 24 h · 29 fuentes · actualizado hace 24 min
Revista de investigación biomédica con revisión por pares. Revista científica · Internacional · Sitio oficial.
8 notas · Solo en español
Nature Medicine, Published online: 29 September 2026; doi:10.1038/s41591-026-04693-z In a phase 1 trial, inhibition of the Werner syndrome helicase (WRN) enzyme exploits a new synthetic lethal vulnerability in cancers with microsatellite instability, offering a new way to target these tumors beyond immune checkpoint inhibition.
Nature Medicine, Published online: 29 September 2026; doi:10.1038/s41591-026-04651-9 The OUTSTAND-1 trial showed that once-daily oral small-molecule GLP-1 receptor agonist safiglipron reduced HbA1c by up to 1.45% versus placebo over 32 weeks in people with type 2 diabetes without glucose-lowering medication while body weight effects were…
Nature Medicine, Published online: 29 September 2026; doi:10.1038/s41591-026-04657-3 In the dose-escalation stage of a phase 1 trial evaluating RO7589831, a first-in-class inhibitor of the synthetic lethal target Werner syndrome helicase, in patients with microsatellite instability and/or DNA mismatch repair-deficient solid tumors, the maximum tolerated dose…
Nature Medicine, Published online: 29 September 2026; doi:10.1038/s41591-026-04667-1 Reproducibility is a foundational principle of trustworthy science, but reproducible research practices are not consistently implemented. This Review summarizes the current landscape including efforts to harmonize terminology and implementation, persistent barriers and ecosystem responses.
Nature Medicine, Published online: 28 September 2026; doi:10.1038/s41591-026-04698-8 When detecting Ebola is not enough: closing the response interval in DRC
Nature Medicine, Published online: 28 September 2026; doi:10.1038/d41591-026-00049-9 A technique known as prime assembly expands the capabilities of prime editing, allowing larger genome rearrangements and potentially wider clinical applications.
Nature Medicine, Published online: 28 September 2026; doi:10.1038/d41591-026-00048-w Using data from over 3 million people, researchers trace the ancestral history of the EGFR T790M germline mutation and its present contribution to lung cancer risk in those who never smoked.
Nature Medicine, Published online: 25 September 2026; doi:10.1038/s41591-026-04684-0 Polygenic scores in the NHS: the debate is not primarily about the evidence
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