Martes 29 de septiembre de 2026 · 151 publicaciones en las últimas 24 h · 29 fuentes · actualizado hace 9 min
Artículos recién publicados en revistas médicas con revisión por pares, de Estados Unidos, Europa y América Latina. Los preprints de medRxiv se marcan aparte: son resultados preliminares que todavía no pasan revisión por pares.
139 notas · Solo en español
BackgroundClonal hematopoiesis of indeterminate potential (CHIP) is associated with ageing and atherosclerotic coronary artery disease (CAD), but evidence has largely come from peripheral blood. Whether somatic mutational profiles differ between arterial tissue and blood, and whether hematopoietic clones are represented in arterial tissue, remain poorly…
BackgroundContinuous glucose monitoring-derived time in range (TIR; glucose 70-180 mg/dL) has emerged as a complementary glycemic metric, but its association with DKD (Diabetic Kidney Disease) has not been systematically quantified. We aimed to synthesize the evidence on the association between CGM-derived TIR and DKD in…
BackgroundFospropofol disodium is a water-soluble prodrug of propofol that avoids a lipid emulsion carrier. It may therefore reduce injection pain, cardiorespiratory depression and lipid exposure. In May 2021 it was approved in China (H20210017) for induction of general anaesthesia in adults. Randomised trials have since…
BackgroundPremature ovarian insufficiency (POI) is a condition affecting female fertility e.g., in the context of autoimmune disease. A recent proof-of-concept study showed that B-cell depletion with rituximab (RTX) temporarily restored ovarian function in patients with autoimmune POI. However, the underlying immunological mechanisms behind this response…
BackgroundRoutinely collected health data can reveal recorded care around diagnosis, but disease-specific curation does not scale across thousands of conditions. We scaled a previously developed automated framework that reduces heterogeneous clinical events into standardised, diagnosis-centred summaries of real-world care patterns. MethodsIn this retrospective observational study…
ObjectivesTo determine whether single-layer evaluation characterises clinical risk in the final note of a multilingual ambient AI scribe, and where serious errors arise. DesignTwo-arm evaluation on one common clinical-risk scale, using a frozen, reference-aligned synthetic corpus. SettingScripted consultations spanning 77 languages and five complexity levels…
BackgroundMalaria in pregnancy (MiP) imposes a substantial economic burden on households in sub-Saharan Africa. We estimated household costs of MiP and their distribution across wealth quintiles among HIV-uninfected pregnant women in western Kenya receiving intermittent preventive treatment (IPTp) with sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine (DP), or dihydroartemisinin-piperaquine…
Wastewater-based epidemiology (WBE) has become a valuable tool to monitor pathogens from community and municipal sources. Whereas the detection of a pathogen in wastewater can help public health agencies understand what is present in a community, it cannot provide insight into a populations preexisting immunity…
Cellular mechanisms in early Alzheimers disease (AD) remain poorly understood despite generation of extensive observational multiomic data. Weighted integration across diverse datasets can prioritise convergent mechanisms and targets. We conducted a systematic review to identify datasets profiling cell-type-specific changes in early AD. We integrated multiomic…
BackgroundNHS-Galleri did not reach its prespecified primary endpoint of a reduction in combined stage III and IV cases, but reported fewer stage IV cancers after annual multi-cancer early detection screening. We estimated the potential five-year life-years associated with the cancer-specific stage IV differences observed during…
AO_SCPLOWBSTRACTC_SCPLOWO_ST_ABSIntroductionC_ST_ABSPolyunsaturated fatty acid (PUFA) status is an important marker of metabolic health across the lifespan, and omega-3 (n-3) PUFA were shown to have anti-inflammatory and cardioprotective effects. The omega-3 index, a composite of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is widely used to assess…
BackgroundEvaluating fairness in artificial intelligence (AI) is essential before clinical implementation to prevent unintended harm across diverse patient populations. This study assesses performance differences of an image-based surgical site infection (SSI) detection model across age, gender, geography, race, and skin color. MethodsModel development/validation study using…
ObjectiveTo assess the knowledge, willingness and barriers to human papillomavirus (HPV) vaccination among caregivers of adolescent girls living with HIV in Sierra Leone. MethodsThis cross-sectional study examined HPV vaccine knowledge, willingness, and barriers among 249 caregivers of adolescent girls living with HIV in Sierra Leone…
BackgroundSince the COVID-19 pandemic, parental delays and refusals of well-established, safe, and effective childhood vaccinations have contributed to the resurgence of infectious diseases. This raises concerns that COVID-19 vaccine hesitancy may also extend to novel vaccines for children when introduced in the future. This study…
BackgroundModern contraceptive use remains low in many sub-Saharan African countries, including Mozambique, limiting progress towards sexual and reproductive health and Sustainable Development Goals (SDGs). Understanding the prevalence, determinants, and inequalities in modern contraceptive use based on Mozambique-wide national survey is critical to informing effective family…
BackgroundNipah virus (NiV) is a zoonotic pathogen in the Henipavirus genus that causes severe, often fatal disease in humans. The World Health Organization and the Coalition for Epidemic Preparedness Innovations (CEPI) have designated NiV as a priority pathogen with pandemic potential. While CEPI is funding…
BackgroundIn Ethiopia as other Sub-Sharan African countries malaria in pregnancy is a major public health threat particularly in the rural communities. Immunosuppression during pregnancy increases the risk of placental malaria; this, in turn, leads to anemia, low birth weight, preterm delivery, and stillbirth, causing severe…
Infectología y vacunasSalud de la mujer y embarazoSalud pública y sistemas de salud
BackgroundSchizophrenia liability reflects both the aggregate effects of many common genetic variants and rare structural variation at recurrent neurodevelopmental copy-number variant (ND-CNV) loci. Although both components of genetic liability have been associated with schizophrenia and related phenotypes, it remains unclear whether they exhibit similar neuropsychiatric…
BackgroundSocial isolation (SI) is an established risk factor for chronic disease and mortality. How people travel, including the modes of transportation they use, may shape opportunities for social interaction and influence the impacts of SI. This study assessed heterogeneity of the association between SI and…
Population-scale pathogen surveillance is limited worldwide, particularly in resource-constrained settings, where clinical systems only monitor select priority pathogens and reach only those who can access healthcare. Wastewater-based epidemiology addresses many of these gaps, offering cost-effective surveillance that is adaptable across diverse implementation contexts. In Lagos…
BackgroundIn rural Alaska, where most communities lack road access, air ambulances serve as a critical link between remote communities and hospital services. ObjectiveTo examine how air ambulance utilization decisions are made within the rural Alaskan health organization ecosystem. MethodsWe conducted semi-structured interviews with five key…
BackgroundThe progression of abdominal aortic aneurysm (AAA) is closely associated with the phenotypic switch of vascular smooth muscle cells (VSMC). While members of the Serine/Arginine-rich splicing factor (SRs) superfamily are increasingly acknowledged for their pivotal role in modulating cell phenotype, the specific contribution of these…
by Manman Chen, Wanzhou Wang, Feng Sha, Zichen Ye, Yuankai Zhao, Chao Yang, Ze Liang, Yu Jiang, Xijie Wang, Jinling Tang Background Global distribution of human resources for health (HRH) is highly unequal and less resourced regions may particularly be vulnerable to disastrous emergencies. We…
The Pan American Health Organization (PAHO) issued an epidemiological alert, calling on nations in the Americas region to strengthen vaccination, surveillance, and response amid a rising number of measles cases.
Actions by US Immigration and Customs Enforcement (ICE) in early 2026 may have disrupted pediatric outpatient care, a recent study suggests.
Objectively measured physical fitness was associated with lower all-cause mortality in older adults in a recent study. The findings, published in JAMA Network Open, could have implications for clinical care, the authors said.
This Medical News article discusses the estimated population-level effects of the 2025 blood pressure guideline, which expanded antihypertensive treatment eligibility.
This Medical News article discusses a new scientific statement from the American College of Cardiology about caring for older adults with cardiovascular disease.
The ADVOCATE initiative and how autonomous AI agents could help patients with heart failure are discussed by JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, and Haider Warraich, MD, a cardiologist and the program manager at ARPA-H, for the JAMA+ AI Conversations podcast.
In this narrative medicine essay, a maternal-fetal medicine physician trained to use clinical terms for developmental stages of pregnancy as an emotional stay against an uncertain outcome experiences tension between clinical and lived language during his wife’s miscarriage.
The Original Investigation titled “Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis,” published on October 3, 2023, was corrected to update Supplement 2. In the original supplement, eTable 21 and eTable 22 were identical and did not have the correct information…
Picasso would have been suited to depict the scene of the hole and the people around it,
Medicine trains clinicians in a particular silence. Through diagnosis, we medicalize the causes of suffering—contusion, laceration, hemorrhage—as though renaming anguish might contain it, keeping it from spilling out of charts and into our own lives. Operating room and ward become, ironically, fluent in the language…
The Original Investigation titled “Global Burden of Elevated LDL-C: Findings From the Global Burden of Disease Study 2023,” published July 29, 2026, was corrected to update the author affiliations list. This article was corrected online.
This Viewpoint discusses how consolidation in frontline care delivery has shaped health care markets across the US and how changes in ownership of hospitals and practices affect clinicians and patient outcomes.
In the JAMA Clinical Guidelines Synopsis titled “Antiviral Therapies for Adults With Mild to Moderate COVID-19 Infection,” published online June 30, 2026, several points were rewritten for clarification. In the third paragraph of the Evidence Base section, the second sentence was revised to “Coadministration of…
This study examines whether emerging drug and diagnostic resistance variants are contributing to Ethiopia’s malaria resurgence.
To the Editor Dr Renú and colleagues reported that adjunctive intra-arterial alteplase after successful thrombectomy “may improve functional recovery” in large vessel occlusion stroke. The randomized clinical trial provides an important test of a plausible reperfusion strategy, but the report leaves a key issue unresolved—the…
In Reply As described in the original report, the primary outcome was amended at month 12 to improve clinical relevance and interpretability, considering emerging randomized evidence and the established use of the blinded mRS score assessment. The amendment was implemented on February 10, 2025, after…
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