Noticias de medicina

JAMARevista científica21 sept.EN

The Hole

Picasso would have been suited to depict the scene of the hole and the people around it,

JAMARevista científica21 sept.EN

“The Hole”: Poetry Like a Gunshot Wound

Medicine trains clinicians in a particular silence. Through diagnosis, we medicalize the causes of suffering—contusion, laceration, hemorrhage—as though renaming anguish might contain it, keeping it from spilling out of charts and into our own lives. Operating room and ward become, ironically, fluent in the language…

JAMARevista científica21 sept.EN

Affiliations Updated

The Original Investigation titled “Global Burden of Elevated LDL-C: Findings From the Global Burden of Disease Study 2023,” published July 29, 2026, was corrected to update the author affiliations list. This article was corrected online.

JAMARevista científica21 sept.EN

Health Care Ownership and Patient Care

This Viewpoint discusses how consolidation in frontline care delivery has shaped health care markets across the US and how changes in ownership of hospitals and practices affect clinicians and patient outcomes.

JAMARevista científica21 sept.EN

Clarifications in JAMA Clinical Guidelines Synopsis

In the JAMA Clinical Guidelines Synopsis titled “Antiviral Therapies for Adults With Mild to Moderate COVID-19 Infection,” published online June 30, 2026, several points were rewritten for clarification. In the third paragraph of the Evidence Base section, the second sentence was revised to “Coadministration of…

Infectología y vacunas

JAMARevista científica21 sept.EN

Resurgence of Malaria in Ethiopia

This study examines whether emerging drug and diagnostic resistance variants are contributing to Ethiopia’s malaria resurgence.

Infectología y vacunas

JAMARevista científica21 sept.EN

Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke

To the Editor Dr Renú and colleagues reported that adjunctive intra-arterial alteplase after successful thrombectomy “may improve functional recovery” in large vessel occlusion stroke. The randomized clinical trial provides an important test of a plausible reperfusion strategy, but the report leaves a key issue unresolved—the…

Cardiología

JAMARevista científica21 sept.EN

Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke—Reply

In Reply As described in the original report, the primary outcome was amended at month 12 to improve clinical relevance and interpretability, considering emerging randomized evidence and the established use of the blinded mRS score assessment. The amendment was implemented on February 10, 2025, after…

Cardiología

JAMARevista científica21 sept.EN

Review of Prepregnancy Care and Counseling

To the Editor I appreciate the expanded women’s health learning opportunities provided by the JAMA Network journals under the editorial leadership of Linda Brubaker, MD, MS. The comprehensive Review of prepregnancy care and counseling by Dr Cooper and colleagues will be a valuable resource for…

Salud de la mujer y embarazo

JAMARevista científica21 sept.EN

Review of Prepregnancy Care and Counseling

To the Editor In reading the otherwise comprehensive article by Dr Cooper and colleagues on prepregnancy care and counseling, we were surprised by the lack of discussion about testing for iron deficiency. Iron deficiency, the world’s most common micronutrient deficiency, is epidemic in young women…

Salud de la mujer y embarazo

JAMARevista científica21 sept.EN

Review of Prepregnancy Care and Counseling—Reply

In Reply We thank Dr Barbieri and Drs Auerbach and DeLoughery for their comments. With regard to Barbieri’s Letter on HCV screening, the US Preventive Services Task Force recommendation is for adults aged 18 to 79 years. We agree with screening reproductive-aged female patients for…

Salud de la mujer y embarazo

JAMARevista científica21 sept.EN

Exclusion of HIV-Positive Patients From Sickle Cell Gene Therapy

This Perspective discusses the ethical, scientific, clinical, and manufacturing implications of excluding patients living with HIV from gene therapies for sickle cell disease.

Infectología y vacunasInteligencia artificial y tecnología

JAMARevista científica21 sept.EN

Suicide Mortality After Launch of the 988 Lifeline

To the Editor Dr Patel and colleagues reported that the national launch of the 988 Suicide and Crisis Lifeline was associated with an 11% reduction in adolescent and young adult suicide deaths (4372 fewer than expected). These findings suggest that a phone-based open-access crisis service…

Salud mentalSalud pública y sistemas de salud

JAMARevista científica21 sept.EN

Suicide Mortality After Launch of the 988 Lifeline

To the Editor Dr Patel and colleagues’ recent article provided promising evidence that the 988 Suicide and Crisis Lifeline has been successful at preventing suicide death. Indeed, their results comparing “high-uptake” and “low-uptake” states are consistent with a time-series analysis of pre–988 Lifeline data that…

Salud mentalSalud pública y sistemas de salud

JAMARevista científica21 sept.EN

Suicide Mortality After Launch of the 988 Lifeline—Reply

In Reply We thank Dr Herring and Dr Purtle for their thoughtful comments. Our study found that suicide mortality among adolescents and young adults decreased after the national launch of the 988 Lifeline, that declines were largest in states where the 988 Lifeline uptake increased…

Salud mentalSalud pública y sistemas de salud

JAMARevista científica21 sept.EN

Optimizing the Therapeutic Ratio in Prostate Radiation Therapy

Prostate cancer has long served as a fertile ground for innovation in cancer therapy. Compared with many other malignancies, localized prostate cancer occupies a unique clinical space. Although the incidence of new diagnoses is high, prostate cancer often follows an indolent natural history, resulting in…

Oncología

JAMARevista científica21 sept.EN

Stereotactic Body Radiotherapy vs Moderately Hypofractionated IMRT for Prostate Cancer

This randomized clinical trial assesses whether stereotactic body radiotherapy is superior to moderately hypofractionated intensity-modulated radiation therapy in terms of patient-reported urinary irritative/obstructive and bowel quality of life and disease-free survival in patients with localized intermediate-risk prostate cancer.

Oncología

JAMARevista científica21 sept.EN

Stereotactic Body Radiotherapy vs Moderately Hypofractionated IMRT for Localized Intermediate-Risk Prostate Cancer Research Summary

The objective of this study was to assess whether stereotactic body radiotherapy (SBRT) was superior to moderately hypofractionated intensity-modulated radiation therapy (MH-IMRT) for urinary and bowel quality of life and disease-free survival in patients with localized intermediate-risk prostate cancer.

Oncología

JAMARevista científica21 sept.EN

Total Intravenous vs Volatile Inhalational Anesthesia for Major Noncardiac Surgery

This randomized trial assesses the effect of use of total intravenous anesthesia on days alive and at home 30 days after surgery among older adults undergoing major noncardiac surgery.

Cardiología

JAMARevista científica21 sept.EN

Total Intravenous vs Volatile Inhalational Anesthesia for Major Noncardiac Surgery Research Summary

This trial examined whether general anesthesia maintenance with total intravenous anesthesia (TIVA) improves patient outcomes compared with volatile-based inhalational anesthesia among adults aged ≥50 years undergoing major elective noncardiac surgery.

Cardiología

JAMARevista científica21 sept.EN

Nicotine Pouches

This JAMA Insights examines the use of nicotine pouches in the US, including adverse effects, comparisons with cigarette and e-cigarette use, and concerns regarding increased use among adolescents and young adults.

JAMARevista científica21 sept.EN

Patient Information: Nicotine Pouches

This JAMA Patient Page describes nicotine patch use, the possible harms and side effects, accidental use, and dependence.

JAMARevista científica21 sept.EN

Nurturing Care for Term Small-for-Gestational-Age Infants

An estimated 250 million children in low- and middle-income countries are unable to meet key developmental milestones due to biological, psychological, and social risk factors, including maternal and child malnutrition, maternal depression, and inadequate early stimulation opportunities. Without early intervention, these adversities pose threats to…

PediatríaSalud de la mujer y embarazo

JAMARevista científica21 sept.EN

Multidomain Intervention for Growth in Term Small-for-Gestational-Age Infants

This randomized trial assesses the effect of an integrated intervention package including health, nutrition, early child stimulation, and maternal psychosocial support on weight and weight-for-age z scores among term small-for-gestational-age (SGA) infants in a low-resource setting.

Pediatría

JAMARevista científica21 sept.EN

Multidomain Intervention for Growth in Term Small-for-Gestational-Age Infants Research Summary

This clinical trial investigated whether an integrated health, nutrition, and early stimulation intervention during infancy improves growth in term small-for-gestational-age (SGA) infants.

Pediatría

JAMARevista científica21 sept.EN

Ulcerative Colitis Management in Adults

This JAMA Clinical Guidelines Synopsis summarizes the American College of Gastroenterology’s (ACG) 2025 clinical guideline update on management of ulcerative colitis in adults.

JAMARevista científica21 sept.EN

Ceperognastat in Alzheimer Disease

Alzheimer disease is defined by the accumulation of extracellular amyloid-β plaques and intraneuronal neurofibrillary tangles composed of hyperphosphorylated tau. For many years, drug development efforts have focused on amyloid-β plaques, culminating in the recent approval of the amyloid-targeting monoclonal antibodies lecanemab and donanemab for the…

NeurologíaMedicamentos y regulación

JAMARevista científica21 sept.EN

Ceperognastat in Early Symptomatic Alzheimer Disease

This randomized clinical trial examines the efficacy and safety of the potent oral O-linked N-acetylglucosaminidase inhibitor ceperognastat in early symptomatic Alzheimer disease.

Neurología

JAMARevista científica21 sept.EN

Ceperognastat in Early Symptomatic Alzheimer Disease Research Summary

This study evaluated whether the oral O-linked N-acetylglucosaminidase inhibitor ceperognastat, at doses of 0.75 and 3 mg, compared with placebo, slows clinical progression in patients with early symptomatic Alzheimer disease with low to medium tau levels.

Neurología

PLOSPLOS MedicineRevista científica21 sept.EN

Association of a multiple risk factor assessment and intervention program with risk of diabetes: A population-based matched cohort study

by Ernst Bergman, Anna Nordström, Lars Nyberg, Peter Nordström Background Type 2 diabetes incidence remains high among older adults and contributes substantially to morbidity and healthcare burden. Most evidence supporting diabetes prevention derives from intensive lifestyle interventions targeting high-risk individuals under controlled trial conditions. The…

Diabetes, obesidad y metabolismo